Calyxo, Inc. presented new data at the European Association of Urology 2025 Annual Meeting (EAU25) showcasing the effectiveness of their CVAC System for kidney stone removal. The key points include:

• The CVAC System is designed with three unique features: microjet irrigation, simultaneous flow, and a large outflow lumen, which work together to maximize kidney stone fragment aspiration.
• The CVAC system demonstrated significantly superior (p<0.001) aspiration rates vs. direct in-scope suction (DISS) across all five size groups.
• A comparative study showed the CVAC System aspirates stone fragments 6-30 times faster than DISS across all tested stone sizes. For a 15mm stone broken into 0.6mm fragments, the CVAC System would take 1.2 minutes compared to DISS’s 34.9 minutes.
• The system maintains low intra-renal pressure regardless of anatomical variations, providing better safety compared to standard ureteroscopy (particularly in non-compliant ureter models).
• In a real-world study at UC San Diego using the next-generation CVAC System 2.0, most patients achieved greater than 99% stone clearance.
• The company positions the CVAC System as an emerging standard of care in kidney stone removal, citing its safety, efficacy, and potential benefits for healthcare utilization.

Learn more here: https://www.businesswire.com/news/home/20250325759364/en/Calyxo-Announces-New-Data-Demonstrating-CVAC-System-Maximizes-Stone-Clearance-While-Maintaining-Safe-Intrarenal-Pressure